Authors
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Geoff Kerchner, MD, PhD: Phase III Trials of Crenezumab in Treatment of Prodromal to Mild AlzheimerData back a 4-fold higher dose of crenezumab in the CREAD 1 and CREAD 2 trials than used in phase II.
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Targeting the NF-kB Pathway in Duchenne Muscular DystrophyAn in-depth analysis of the genetics of DMD and disease modifiers such as the NF-kB pathway in patients with Duchenne muscular dystrophy.
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Daniel M. Goldenholz, MD, PhD: Assessing the Risk for SUDEPThe instructor in neurology at Beth Israel Deaconess Medical Center spoke about what clinicians can do right now to mitigate the risk of SUDEP and the myriad of options for them to utilize.
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World Alzheimer Day 2019: Key Takeaways From Leaders in Alzheimer Disease and DementiaIn recognition of World Alzheimer Day, experts in Alzheimer disease and dementia share insight from the latest Alzheimer Disease International's yearly World Alzheimer Report.
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Predicting Response to Cannabinoid Treatment for Agitation in Alzheimer Disease: Krista L. Lanctôt, PhDThe professor of psychiatry and pharmacology at the University of Toronto talked about results from a post hoc analysis presented at CTAD 2024 that explored synthetic cannabinoid nabilone for agitation in Alzheimer disease. [WATCH TIME: 4 minutes]
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Dina Katabi, PhD: Biosensors for Measuring Disease Activity in MS and Other Neurological DisordersThe Andrew & Erna Viterbi Professor of Electrical Engineering and Computer Science at MIT spoke about a new way of continuous monitoring for patients with MS and neurodegenerative disorders, discovering changes in quality of life and new biomarkers.
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Screening for Alzheimer Disease: Facilitating an Early Diagnosis for Prompt InterventionIn this episode of MEDcast, expert geriatric psychiatrists explore the urgent need for effective diagnostic methods that can detect Alzheimer’s disease at an early stage. We will discuss blood-based biomarkers and other advancements that can help screen Alzheimer’s disease non-invasively and early in the disease course.
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State of Migraine Care and Therapeutics: Richard B. Lipton, MDThe director of the Montefiore Headache Center provided an overview of the recent advances in migraine medications and how it has translated to improved care. [WATCH TIME: 2 minutes]
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Overviewing Positive Phase 2 Data on Potassium Channel Inhibitor XEN1101: Jacqueline French, MDThe professor of neurology at NYU Grossman School of Medicine discussed the results of a phase 2b study on XEN1101, an investigational drug in development for focal epilepsy. [WATCH TIME: 4 minutes]
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Revised McDonald Diagnostic Criteria Signals New Era in Multiple Sclerosis TreatmentThe 2024 revisions to the McDonald diagnostic criteria for multiple sclerosis (MS) mark a significant advancement in the early detection and diagnosis of the disease, with new biomarkers and a broadened scope that may lead to earlier intervention and improved patient outcomes.
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Antje Bischof, MD: Understanding Vasculitic NeuropathyThe postdoctoral scholar at the University of California San Francisco discussed the findings from her study that gives comprehensive insight into prevalence and organ associations of vasculitic neuropathy.
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Final Advice for Clinicians Treating NarcolepsyDrs Thorpy, Dogan, Doghramji, and Kushida share clinical pearls for primary care providers who are taking care of patients with narcolepsy.
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Glenn Wylie, DPhil: The Future of Real-Time NeurofeedbackThe director of the Rocco Ortenzio Neuroimaging Center at Kessler Foundation spoke about the future of functional MRI in providing real-time neurofeedback, and how it might be incorporated as an end point in clinical trials.
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Erin Conrad, MD: Identifying the Seizure Onset ZoneThe epilepsy fellow at the hospital of the University of Pennsylvania detailed why locating the seizure onset zone plays a crucial role in successful epilepsy surgery.
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Fred Rincon, MD, MSc : Expanding Stroke Treatment Outside of NeurologyThe chief of cerebrovascular disease at Jefferson University Hospitals explains why teaching stroke protocol and using telemedicine can help close the gaps in stroke care.
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Targeting the Neonatal Fc Receptor in Myasthenia GravisUnderstanding the pathophysiology of myasthenia gravis is still being determined to this day, but the neonatal Fc receptor is emerging as a potential treatment.
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Exploring Synergistic Treatment Strategies for Migraine With Monoclonal Antibodies and Gepants: Stewart J Tepper, MDThe professor of neurology at the Geisel School of Medicine at Dartmouth talked about recent studies presented at the International Headache Congress on a potential migraine prevention treatment targeting pituitary adenylate cyclase activating polypeptide. [WATCH TIME: 5 minutes]
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Marie D'hooghe, MD, PhD: Pregnancy Plans for Patients With MSThe neurologist at the National MS Center and University Hospital, in Brussels, discussed the clinician mindset when treating women with MS who plan to get pregnant, and how patients using assistive reproductive treatments should be approached.
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Elizabeth Thiele, MD, PhD: CBD Shows Low-Dose Efficacy and Safety in TSCThe director of pediatric epilepsy and the Herscot Center for Tuberous Sclerosis Complex at Massachusetts General Hospital, and professor of neurology at Harvard Medical School spoke to the safety outcomes from GWPCARE6 and CBD’s low-dose efficacy.
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Exploring the Potential Therapeutic Avenue of BTK Inhibitors for Progressive MS: Amit Bar-Or, MD, FRCPC, FAAN, FANAThe Melissa and Paul Anderson President’s Distinguished Professor of Neurology, Perelman School of Medicine, University of Pennsylvania, discussed the promising avenue of BTK inhibitors for addressing progressive multiple sclerosis. [WATCH TIME: 5 minutes]
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Brian J. Murray, MD: Establishing Normal Values in PolysomnographyThe head of neurology at the Sunnybrook Health Sciences Centre of the University of Toronto spoke about the limited available normative sleep data, and shared insight into the findings of the meta-analysis he and colleagues conducted of more than 150 studies.
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Progress for Patients With Pediatric MS, Fingolimod's Risk-Benefit Profile: Brenda Banwell, MDThe chief of neurology and codirector of the neuroscience Center at the Children's Hospital of Philadelphia spoke about her presentation at ECTRIMS 2022 on the treatment of pediatric MS. [WATCH TIME: 5 minutes]
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Thorsten Mikoteit, MD: Sleep Research, an Excellent Source for BiomarkersThe Psychiatrist at Psychiatric Services Solothurn and University of Basel discussed how heart rate variability correlates with sleep stages, which may indicate nocturnal brain activity.
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Lifestyle Change for Migraine Management: Practical Tips for the Neurologist and PCP, Part 2Trigger avoidance-only strategies don’t actually help migraine patients improve. These are the proactive behaviors that do.
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Spinal Muscular Atrophy and COVID-19: Guidance and Resources for ProvidersAdvocacy organization Cure SMA provides guidance for health care providers caring for patients with SMA during the ongoing COVID-19 pandemic.
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The Challenges of Stroke Care in Rural AmericaStroke care, including acute treatment and prevention, faces unique challenges in rural areas where disease awareness is lacking and access to high-level care in scarce.
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The Potential of NLRX1 in Immune Regulation and Neuroprotection for Inflammatory Neurodegenerative Disorders: Marjan Gharagozloo, PhDThe assistant professor of neurology at Johns Hopkins Medicine talked about her preclinical research in immunology to explore the intricate mechanisms controlling chronic inflammation in the central nervous system. [WATCH TIME: 5 minutes]
