In this roundtable discussion, Moein Amin, MD, Marisa McGinley, DO, and Devon Conway, MD,explored key developments in multiple sclerosis (MS) treatment and research. The panelists discussed which sessions in the meeting could have the most immediate impact on clinical practice, as well as the potential for emerging therapies like BTK inhibitors and CAR T-cell therapy to reshape MS treatment. They also delve into the promising applications of AI and machine learning in MS, while addressing the challenges that remain. The conversation further touched on the increasing focus on aging and MS progression, with the experts sharing insights on managing aging-related factors in MS care.