Episode 133: Clinical Guidance on Neuromodulation for Lennox-Gastaut Syndrome

Depobam Samanta, MD, MS, FAAP, FAES

Episode 133 of the NeurologyLive^® Mind Moments^® podcast is now live! Scroll down to listen or click here to subscribe on your favorite streaming service.

The Mind Moments podcast features exclusive interviews with leaders in the field discussing the latest research and disease management strategies across the breadth of neurology, including epilepsy, multiple sclerosis, Parkinson disease, dementia, sleep disorders, and more.

In this episode, "Clinical Guidance on Neuromodulation for Lennox-Gastaut Syndrome," epilepsy expert Depobam Samanta, MD, MS, FAAP, FAES, sat down to discuss a recently published guidance paper from members of the Pediatric Epilepsy Research Consortium that provides recommendations for using neuromodulation approaches to treat Lennox-Gastaut syndrome (LGS). Samanta, medical director of the Arkansas Children's Comprehensive Epilepsy Program, gave a clinical overview of the paper, highlighting the various neuromodulatory devices and their use, and the ways to improve treatment selection and personalization. Additionally, he talked about some of the potential complications with these devices as well as initiation and titration strategies for easy initiation. Furthermore, he spoke about ways to take neuromodulation to the next level, giving insight on creative trial designs, overcoming sham-controlled studies, and the necessary research to expand these approaches.

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

• FDA Accepts BLA for Subcutaneous Autoinjector Formulation of Lecanemab
• Cell Therapy Bemdaneprocel Advances to Phases 3 Registrational Trial in Parkinson Disease
• Real-World Study Highlights Positive Treatment Benefits of Tofersen on ALS Disease Progression, Function

EPISODE BREAKDOWN

• 1:05 – Overview of the published guidance and reasons behind the paper 
• 5:15 – Patient selection for neuromodulation and tailoring treatments by patient and preference
• 8:25 – Overcoming complications with neuromodulation devices 
• 11:25 – Multidisciplinary team necessary for successful implementation of neuromodulation
• 13:15 – Neurology News Minute
• 15:15 – Initiation and titration strategies for vagus nerve stimulation, deep brain stimulation, and resective surgery
• 18:30 – Next steps in research and expanding neuromodulation for patients with LGS
• 21:10 – Finding creative trial designs to test neuromodulation devices, combination approaches

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