Clinical Takeaways
- Neuronal blood extracellular vesicles containing α-synuclein (α-Syn) could be a promising diagnostic tool for Parkinson disease (PD).
- The diagnostic potential of extracellular vesicles (EVs) is particularly notable in blood plasma, especially when using L1CAM-immunoprecipitation to isolate α-synuclein.
- Oligomeric α-Syn, a toxic form of the protein, may serve as a more robust biomarker for PD, offering insights into the disease's progression and mechanisms.