Assistant Professor, Department of Neurology, Neuroimmunology and Multiple Sclerosis; Director, Neuroimmunology and MS Fellowship Program, The Medical College of Wisconsin
Question and Answer about Neurofilament Light Chain and Other MS Biomarkers
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, answer questions about biomarkers in MS care.
Biomarkers, Patient Communication, and the Future of Care
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, discuss future directions in MS amid increasing advances in the field.
Understanding the Underlying Progression of Multiple Sclerosis
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, discuss the limitations of neurofilament light chain in identifying disease progression.
Reimbursement for MRI
Mark Freedman, MD, MSc; Tanuja Chitnis, MD; and Ahmed Obeidat, MD, PhD, discusses the challenges associated with the cost of MRI and other important tools in the monitoring and assessment of MS.
The CLIMB Study
Tanuja Chitnis, MD, discusses the CLIMB database and study to identify predictors of future disease and determine the effect of treatment on progressions and disability.
Neurofilament Light Chain and MS Prognosis, Treatment Effect, and Anticipation of Disease
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, contextualize data from large studies regarding the utilization of neurofilament light chain.
Assessing Lesion Types With MS Biomarkers
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, discuss how use of biomarkers has affected understanding and assessment of lesion types.
Monitoring Patients After a Change in Treatment Regimen
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, review conditions under which they would assess treatment success for patients who have changed therapies.
Weighing Treatment Decisions Based on Neurofilament Light Chain Levels
Thought leaders explore treatment possibilities in patients with irregular NFL patterns.
How to Address Increasing Neurofilament Light Chain Levels
Tanuja Chitnis, MD, shares possible course of action if NFL levels begin to rise during treatment.
Practical Considerations for the Use of Neurofilament Light Chain and MRI
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, raise important questions about the extent to which biomarkers can aid in patient care as well as their limitations.
Exploring Potential Applications of Neurofilament Light Chain in MS Prognosis and Care
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, talk about the practical use of biomarkers in treatment decision making.
Neurofilament Light Chain and Acute Gadolinium Enhancing Lesions
Tanuja Chitnis, MD, explains how higher neurofilament light chain levels can signal disease activity in MS.
Challenges and Opportunity With MRI
Ahmed Obeidat, MD, PhD, recounts the difficulties with MRI as a main biomarker for MS and shares strategies for optimal use of the technology.
Assays to Detect Neurofilament Light
Tanuja Chitnis, MD, discusses the use of ultra-sensitive assays to determine protein levels in the blood, which may aid in the diagnosis of MS.
Evolving Methods of Multiple Sclerosis Diagnosis
Ahmed Obeidat, MD, PhD, considers utility of biomarkers in MS diagnosis, but he also noted that diagnosis remains clinical.
The Value of Biomarker in Multiple Sclerosis
Mark Freedman, MD, MSc, Tanuja Chitnis, MD, and Ahmed Obeidat, MD, PhD, discuss the role of biomarkers and the key areas in which they will be used in managing day-to-day decisions in patient management.
Revealing the Unseen in Multiple Sclerosis
Cognitive and other symptoms in multiple sclerosis can be invisible—meaning not readily observed in the individual. However, their impact on a patient’s life can be obvious.
The Future of Multiple Sclerosis Treatment
Ahmed Obeidat, MD, PhD; Benjamin Greenberg, MD; and Hesham Abboud, MD, share their hopes about the evolution of future mutiple sclerosis care and express their gratitude for the next generation of neurologists.
Novel Mechanisms of Action for Multiple Sclerosis Treatment
Drs Hesham Abboud and Benjamin Greenberg share their excitement for the future of multiple scelrosis treatment and comment on emerging therapies and novel mechanisms of action.
Future Thoughts on BTK Inhibitors in Multiple Sclerosis
Ahmed Obeidat, MD, PhD; Benjamin Greenberg, MD; and Hesham Abboud, MD, discuss their future hopes and concerns for the use of BTK inhibitors in the treatment of multiple sclerosis.
Impact of Route of MS Treatment Administration on Adherence
Drs Ahmed Obeidat, Hesham Abboud, and Benjamin Greenberg share their experiences with patient compliance and the route of administration of current and emerging therapies for multiple sclerosis.
Role of Combination Therapy in Multiple Sclerosis
Experts in neurology debate the utility of combination therapy in the management of multiple sclerosis and highlight current obstacles to this treatment approach both in clinical investigation and practice.
Unmet Needs in Multiple Sclerosis Clinical Trial Design
Ahmed Obeidat, MD, PhD; Benjamin Greenberg, MD; and Hesham Abboud, MD, comment on the need for more inclusive clinical trial patient enrollment criteria, highlighting underserved patient populations.
Using BTK Inhibitors in Clinical Practice for MS Management
Dr Hesham Abboud shares his opinion on the clinical practicalities of BTKi utilization in patients with multiple sclerosis.
Future of Cognition in Multiple Sclerosis
Ahmed Obeidat, MD, PhD; Randall Schapiro, MD, FAAN; and Jeffrey Wilken, PhD, share their hopes for the future of multiple sclerosis treatment and discuss unmet needs and novel targets.
Practical Considerations to Manage Patients With MS and Cognitive Impairment
Experts in neurology discuss practical considerations for the management of multiple sclerosis, tying in the importance of a collaborative care team and patient involvement.
BTKi Safety Considerations in Multiple Sclerosis
Experts in neurology discuss safety concerns and considerations with the use of BTKis in the management of patients with multiple sclerosis.
Progressive Multiple Sclerosis and BTK Inhibitors
Hesham Abboud, MD, provides insight into the impact of the differnet biochemical compositions of the currently investigated BTKis and highlights on-going clinical trials.
DMT Selection Considerations in Patients With Multiple Sclerosis
Randall Schapiro, MD, FAAN, and Jeffrey Wilken, PhD, examine the role that cognition and route of administration play in DMT selection in patients with multiple sclerosis.