Latest Conference Coverage

Pavel Klein, MD: Determining Likelihood of Efficacy and AEs in Patient Populations

The director of the Mid-Atlantic Epilepsy and Sleep Center discussed his team’s investigations into predicting responders and adverse events.

William Rosenfeld, MD: Reducing Concomitant ASM Dosages for Focal Seizures

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed the different medications that cenobamate was used with.

Cenobamate’s Efficacy in Seizure Freedom and Decreasing Concomitant Medication Use

William Rosenfeld, MD, discusses the decreases his team observed in concomitant medication use with cenobamate in patients with focal seizures.

Pavel Klein, MD: Finding the Right AEDs for Patients With Epilepsy

The director of the Mid-Atlantic Epilepsy and Sleep Center urged physicians to catch refractory epilepsy early and look for the most efficacious treatments for their patients.

REM Not Correlated With Increased Risk of SUDEP

Although the percentage of total seizures arising from REM was low, it is notable that 2 out of 26 patients (7.7%) had REM-onset seizures.

William Rosenfeld, MD: Decreasing Concomitant ASM Use With Cenobamate for Epilepsy

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how his team saw a roughly 25% decrease in the mean use of concomitant ASMs.

Pavel Klein, MD: Brivaracetam Efficacy Inversely Proportional to Number of Lifetime AEDs

The director of the Mid-Atlantic Epilepsy and Sleep Center urged physicians to try and find the right medications for their patients as early as possible.

William Rosenfeld, MD: Finding Ideal Combinations of Cenobamate and Concurrent ASMs

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how his team succeeded at titrating cenobamate early in the study.

Pavel Klein, MD: Efficacy of Brivaracetam on Refractory Epilepsy

The director of the Mid-Atlantic Epilepsy and Sleep Center urged physicians to actively look for new medications for patients to try.

William Rosenfeld, MD: Balancing Cenobamate and Concomitant ASMs

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how his team studied the interactions of ASMs and cenobamate.

Pavel Klein, MD: Challenges of Treating Drug-Resistant Epilepsy

The director of the Mid-Atlantic Epilepsy and Sleep Center also noted how serious adverse effects from treatment can be detrimental to patients’ lives.

William Rosenfeld, MD: Observing Interactions of Cenobamate and Concomitant ASMs

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how his team worked to reduce deleterious ASM interactions.

Pavel Klein, MD: Brivaracetam is Benign and Efficacious for Focal Seizures

The director of the Mid-Atlantic Epilepsy and Sleep Center also urged physicians to not give up on the search for effective AEDs for their patients.

Kelly Knupp, MD: Treatment Landscape for Lennox-Gastaut Syndrome

The pediatric neurologist and epilepsy specialist at Colorado Children’s Hospital discussed how the treatment landscape for patients with Lennox-Gastaut syndrome could alter if fenfluramine is approved.

William Rosenfeld, MD: Greater Efficacy of Cenobamate With Fewer Concomitant ASMs

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how patients with intractable epilepsy found cenobamate effective.

Christian Meisel, MD, PhD: Treatment Landscape for Seizure Forecasting Devices

The neurologist from Universitätsmedizin Berlin and Berlin Institute of Health provided his insight on the reasons for the limited number of FDA-approved seizure forecasting devices.

Transdermal CBD Efficacious in Children With Developmental and Epileptic Encephalopathies

Efficacy was observed in patients with DEEs such as West Syndrome, Lennox-Gastaut syndrome, and Dravet syndrome.

NeuroVoices: Eric Segal, MD, on Real World Use of Diazepam Nasal Spray

Eric Segal, MD, director of pediatric epilepsy, HMH Hackensack University Medical Center, detailed his study on diazepam nasal spray in patients with and without antiseizure medications.

Positive Fenfluramine Data in LGS Suggest an FDA Approval Is on the Horizon

Kelly Knupp, MD, pediatric neurologist and epilepsy specialist, Children’s Hospital Colorado, detailed the findings of fenfluramine in patients with Lennox-Gastaut syndrome and how it may shake up the treatment landscape.

CBD Effective Regardless of Infantile Spasm History, Fenfluramine Effective in CDD, Wristband Sensor Data May Predict Seizures

Neurology News Network for the week ending December 12, 2020.

Cannabidiol Maintains Efficacy Long-Term in Tuberous Sclerosis Complex

Seizure reduction was observed to be sustained for up to 192 weeks in the Expanded Access Program data.

Christian Meisel, MD, PhD: Expanding Preliminary Data on Seizure Forecasting

The neurologist from Universitätsmedizin Berlin and Berlin Institute of Health spoke about his study presented at AES 2020 and how the next steps following the positive results.

Fenfluramine Shows Clinical Benefit in Dravet for Adults as Well as Children

The US Early Access Program for fenfluramine allowed access to the treatment for patients who were ineligible for clinical trials.

Long-Term Perampanel Efficacious Regardless of Enzyme-Inducing Anti-Seizure Medications

Patients receiving perampanel in combination with an enzyme-inducing anti-seizure medication may require a higher perampanel dose to achieve similar efficacy with only non-EIASMs.

William Rosenfeld, MD: Enduring Efficacy of Cenobamate

The neurologist from the Comprehensive Epilepsy Care Center for Children and Adults, in St. Louis, Missouri, discussed how patients found cenobamate effective for up to 43 months.

SUDEP Rates Greater Than Previously Reported, Higher Among Nonwhite Children

Study data from the NIH/CDC Sudden Death in the Young (SDY) Case Registry suggest that nonwhite children and infants have rates of SUDEP mortality 1.5 times higher than whites.

Personalized Neuromodulation Therapy Reduces Seizures Safely in Drug-Resistant Epilepsy

Microburst stimulation was also found to be more tolerable than standard stimulation in patients with drug-resistant epilepsy.

Eric Segal, MD: Diazepam Clinical Utility Regardless of Concomitant Benzodiazepines

NeuroVoices: Christian Meisel, MD, PhD, on Forecasting Seizures

Christian Meisel, MD, PhD, department of neurology, Universitätsmedizin Berlin, and Berlin Institute of Health, discussed the landscape for devices that forecast seizures, including the use of multi-modal wristband sensors.

Pediatric Epilepsy Laser Ablation Shows Efficacy With Few Complications

The registry is planning to expand, with 5 additional centers recently agreeing to participate and institutional research ethics applications underway.