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Articles

The investigational therapy was safe, well-tolerated, and showed promising improvements in cognitive measures among patients with dementia with Lewy bodies.

CT1812 Meets Primary End Point in Phase 2 SHIMMER Study for Dementia with Lewy Bodies

Human studies revealed thinner myelin sheaths in CD59-deficient patients, indicative of a process of segmental demyelination followed by remyelination.

Preclinical Study Links CD59 Deficiency to Demyelination and Conduction Blocks

Videos

Neurology News Network. for the week ending December 21, 2024. [WATCH TIME: 4 minutes]

FDA Places Hold on CONNECT2-EDO51, Sevasemten Meets End Point in Becker, Tolebrutinib Gets Breakthrough Therapy Designation

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending December 20, 2024. 

NeurologyLive® Friday 5 — December 20, 2024

Assistant professor of neurosurgery and neuroscience at Mayo Clinic Arizona

The assistant professor of neurosurgery and neuroscience at Mayo Clinic Arizona discussed an ongoing early-stage study assessing the therapeutic potential of NRTX-1001 nerve cell therapy in drug-resistant unilateral mesial temporal lobe epilepsy. [WATCH TIME: 5 minutes]

Studying Nerve Cell Therapy NRTX-1001 to Treat Mesial Temporal Lobe Epilepsy: Jonathan Parker, MD, PhD

, has been with the team since September 2022. Follow her on Twitter 

The program assembles a collaborative team of in-house and external experts in research, clinical care, and regulatory affairs to navigate gene therapy programs through the drug development process.

FDA Grants MDA Kickstart Program Rare Pediatric Disease Designation and Orphan Drug Designation in Congenital Myasthenic Syndrome

IJMSC Insights offers a closer look at the latest research and the people behind it from the community of the International Journal of Multiple Sclerosis Care (IJMSC) and the Consortium of Multiple Sclerosis Centers (CMSC).

IJMSC Insights: Blanca De Dios Perez on Employment and Multiple Sclerosis

Pediatric epilepsy specialist at University of California, San Francisco.

At AES 2024, a duo of pediatric epilepsy specialists discussed how implementation science, validated blood biomarkers, and cross-disciplinary collaboration are advancing epilepsy care and closing research gaps. [WATCH TIME: 3 minutes]

Advancing Epilepsy Research Through Implementation Science and Biomarkers: Adam Numis, MD; Laura Kirkpatrick, MD

NeurologyLive is your direct connection to the latest neurology news and interviews with expert neurologists in multimedia formats.

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Treatment and Management of Mild-to-Moderate Multiple Sclerosis

Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

Do you see mild MS in patients of Different Races and Ethnicities

In a panel discussion, multiple sclerosis (MS) experts Stephen Krieger, MD; Heidi Crayton, MD; Jacqueline Nicholas, MD, PhD; Patricia Coyle, MD, and Enrique Alvarez, MD, PhD, share their insights on current MS therapies, aspirations for guideline revisions, the importance of shared decision-making, and the role of medium-efficacy therapy in the management of mild-to-moderate MS.

Key opinion leaders provide insights into the prevalence and incidence of clinically isolated syndrome (CIS) within their clinical practice.

Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

The panelists explore diagnostic methods for differentiating between mild and moderate multiple sclerosis (MS) while also examining prognostic factors, the role of imaging, and the concept of brain reserve in mild MS cases.

Defining Mild Multiple Sclerosis

Multiple sclerosis (MS) specialists discuss their observations regarding variations in MS presentation and progression among patients of Different Races and Ethnicities

The expert panel examines early multiple sclerosis (MS) and patients with mild MS even in later stages of the disease, emphasizing crucial information to convey to patients throughout their journey; faculty also explore cases where disease-modifying therapies (DMTs) may not be utilized.

Conversations With Patients About Mild/Moderate Multiple Sclerosis

The key opinion leaders provide recommendations on the optimal frequency for evaluating disease progression in patients with mild to moderate MS, emphasizing effective monitoring methods and the most appropriate tools for best clinical practice.

Monitoring Patients With Mild/Moderate Multiple Sclerosis

The panel reflects on their experiences as practicing clinicians, emphasizing the significance of shared decision-making and actively listening to patients’ preferences regarding management of their MS. 

Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

Multiple sclerosis (MS) treatment specialists discuss the challenges associated with the early use of high-efficacy therapy (HET) in patients with mild to moderate MS and delve into the broader debate surrounding the consistent use of HET for managing mild to moderate MS cases.

De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

Key opinion leaders share their approach to treatment sequencing for patients with multiple sclerosis (MS), taking into account comorbidities such as cardiovascular diseases, risk of infection, liver damage, and cancer as well as considering factors like planned pregnancy or advanced age.

Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

The panel explores factors influencing treatment adherence in multiple sclerosis (MS) patients and highlights the importance of shared decision-making in promoting and maintaining patient adherence to their prescribed therapy.

Treatment Adherence in Mild Multiple Sclerosis

Medical experts debate the concept of benign multiple sclerosis (MS), questioning whether this subtype truly exists or if it is a misnomer in the context of the disease's long-term progression and impact on patients.

Benign Multiple Sclerosis

The panel identifies and discusses the unmet needs of patients with mild to moderate multiple sclerosis (MS), highlighting areas where current treatment options and management strategies fall short in addressing the unique challenges faced by this patient population.

Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

Key opinion leaders explore the impact of newly available biosimilars and generic biologics for managing multiple sclerosis (MS), discussing how these developments have altered patient access to treatments and the implications for the future of the MS treatment landscape.

Generics and Biosimilars in Multiple Sclerosis

Key opinion leaders examine the available data on Bruton tyrosine kinase (BTK) inhibitors to assess whether the evidence supports their efficacy as a treatment option for multiple sclerosis (MS).

Emerging Treatments in Mild/Moderate Multiple Sclerosis

In closing, the panel of experts in multiple sclerosis (MS) offer their insights and recommendations for clinicians, emphasizing best practices to optimize patient care and improve overall outcomes in the management of MS.

Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis

Peer Exchange

 Peer Exchange video series features panels of expert physicians engaging in in-depth discussions about practice-changing treatments, challenges in care, and the future paradigm of management for neurologic diseases.

Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

EP: 1.Presentation of Clinically Isolated Syndrome/First Attack of Multiple Sclerosis

EP: 2.Defining Mild Multiple Sclerosis

EP: 3.Mild/Moderate Multiple Sclerosis in Patients of Different Races and Ethnicities

EP: 4.Conversations With Patients About Mild/Moderate Multiple Sclerosis

EP: 5.Monitoring Patients With Mild/Moderate Multiple Sclerosis

EP: 6.Shared Decision-Making for Patients With Mild/Moderate Multiple sclerosis

EP: 7.De-Escalation Strategies and Challenges With the Use of HET in Mild/Moderate Multiple Sclerosis

EP: 8.Choosing Between Moderate Therapies for Mild/Moderate Multiple Sclerosis

EP: 9.Treatment Adherence in Mild Multiple Sclerosis

EP: 10.Benign Multiple Sclerosis

EP: 11.Diagnostic Uncertainty, Monitoring and Other Unmet Needs in Mild/Moderate Multiple Sclerosis

EP: 12.Generics and Biosimilars in Multiple Sclerosis

EP: 13.Emerging Treatments in Mild/Moderate Multiple Sclerosis

EP: 14.Final Thoughts on Caring for Patients With Mild/Moderate Multiple Sclerosis