MS and Demyelinating Disorders

Determining who is at risk for MS remains difficult, and symptoms may take time to develop even in patients who already have some destroyed myelin. MRI may help.

A new study provides hope for MS treatment with IGF-1, which could ultimately halt the attack of T effector cells on myelin, thereby stopping disease progression.

New study findings do not suggest a need for a change in vaccine policy, but even a small increased risk could have an effect on public health.

Studies suggest that acupuncture can improve MS-related symptoms, but poor design makes it difficult to draw robust conclusions.

This, the least common MS disease course, carries the worst prognosis. Treatments are urgently needed to prevent or delay the rapid disease progression.

Childhood obesity is another potentially modifiable factor to reduce the risk of multiple sclerosis.

If an anti-NMDAR patient has evidence of demyelination on MRI, look for other antibodies that may complicate the picture.

Five recent studies on multiple sclerosis offer new insights: the take-home points are featured in this slide show.

At the ACTRIMS/ECTRIMS conference, one has the impression that the science of multiple sclerosis is moving forward at an unprecedented rapid rate. Live from the floor . . .

Hospitalization rates have declined dramatically in the MS population but remain higher than in the general population. That may be because of the availability of MS disease-modifying treatments.

Information on causes of death for patients with MS is limited, but these researchers came up with some of the underlying causes.

A significant percentage of patients with MS in the sample screened positive for 1 or more sleep disorders. Most were undiagnosed.

This study identified that suicidal thoughts are common and several potentially modifiable factors may be useful for prevention.

This study found a positive relationship between physical disability and anxiety and depression, pointing to a need for routine evaluation.

What emerged is that Devic’s is a distinct syndrome that results in widespread destructive lesions in the spinal cord that are not strictly demyelinating in their onset. Interesting questions remain.

Vitamin D levels during pregnancy do not appear to influence MS risk to any substantial extent.

Given the data from Denmark, being infected with HIV does seem to be “protective” against MS development.

Several lines of evidence indicate that gender affects the susceptibility and course of MS with a higher disease prevalence and overall better prognosis in women.

Here: succinct highlights from new studies may offer you insights about multiple sclerosis you didn't have before.

Out of the blizzard of recently published clinical studies on multiple sclerosis, we've randomly selected 2 with useful information you might not want to -- but easily could -- miss. Here: brief synopses and links.

An unusual cause of postpartum neurologic deficits: MRIs of progressing relapsing-remitting MS; Lhermitte-Duclos disease as a cause of ataxia: here. . . 5 short clinical cases, each with images, that offer take-home messages you can use in your practice.

How do we use Tysabri responsibly? How often should you screen patients taking the medication for the JC virus? What are the considerations for transitioning JC+ patients to another medication-and when is the best time to make the transition?

A new study puts a final nail in the coffin for the hypothesis that chronic cerebrospinal venous insufficiency is neither specific or causative for multiple sclerosis.

In this study, high-dose simvastatin reduced the annualized rate of whole-brain atrophy in secondary progressive MS.

For people with MS, smoking is associated with more severe disease and faster disability progression. Smoking cessation before or after disease onset is associated with slower progression of disability.