MDA’s Focus on Better Access for Patients With Neuromuscular Disorders: Paul Melmeyer
January 25th 2023Ahead of the 2023 MDA Conference, which will be held from March 19-22, 2023, in Dallas, Texas, the vice president of public policy and advocacy at the Muscular Dystrophy Association provided an overview of the current state of access and the need for more advocates in neuromuscular disease. [WATCH TIME: 14 minutes]
Mesdopetam Fails to Improve ON Time But Shows Anti-Dyskinesia Effects in Parkinson Disease
January 25th 2023Mesdopetam showed significant effects on the secondary end point of Unified Dyskinesia Rating Scale, an assessment of involuntary movements associated with long-term treatment with dopaminergic medication.
FDA Accepts Supplemental NDA for Valbenazine as Therapy for Huntington Disease Chorea
January 24th 2023The phase 3 KINECT-HD study, which showed statistically significant differences from placebo in Total Maximal Chorea score, served as one of the main parts to valbenazine’s supplemental new drug application.
Paroxysmal Abnormalities in the Brain and Defining the ‘Seizure’: Michael Sperling, MD
January 23rd 2023At the 2022 AES Conference, the Baldwin Keyes professor of neurology at Thomas Jefferson University, talked about what defines a ‘seizure’ and changing the terminology. [WATCH TIME: 5 minutes]
Growing Brivaracetam’s Potential Through the Adaptive, Dose-Finding EXPAND Study
January 22nd 2023The trial’s 2-stage design seeks to answer questions about the dosing and efficacy of brivaracetam, a previously approved agent for partial-onset seizures in patients with childhood absence epilepsy and juvenile absence epilepsy.
Aβ Protofibril Elimination in Alzheimer Disease
January 21st 2023One model of AD suggests that Aβ pathophysiology triggers downstream molecular pathways, including tauopathy, which lead to cortical neurodegeneration, and cognitive decline is further attributed to the associated neurocortical Aβ plaques.
Weighing Epilepsy Surgery as a Potential Treatment Option for Patients: Scott Perry, MD
January 20th 2023At the 2022 AES Conference, the head of neurosciences at the Jane and John Justin Neurosciences Center of Cook Children’s Medical Center, talked about epilepsy surgery as an alternative for some patients. [WATCH TIME: 5 minutes]
Building Trust in the Epilepsy Clinician-Patient Relationship: Elizabeth Felton, MD, PhD
January 20th 2023The assistant professor in the Department of Neurology at the University of Wisconsin spoke about healthcare providers establishing trust with their patients and improving health equity. [WATCH TIME: 3 minutes]
Real-World Data of Spinal Muscular Atrophy Shows High Adherence to Nusinersen Dosing Regimen
January 20th 2023Nearly 94% of nusinersen doses recorded in electronic health records database and more than 80% of doses recorded in the claims databases were received on time according to the recommended dosing schedule.
Ticagrelor and Aspirin Combination Most Effective in CYP2C19 Carriers With Low Risk Profile
January 19th 2023The study provided class II evidence that CYP2C19 loss of function carriers with minor stroke or transient ischemic attack at low risk, but not high risk, of recurrent stroke received greater benefit from ticagrelor and aspirin rather than clopidogrel and aspirin.
Striving for Health Equity in Epilepsy Care: Elizabeth Felton, MD, PhD
January 19th 2023At the 2022 AES annual meeting, the assistant professor in the Department of Neurology at the University of Wisconsin talked about her presentation and the key actions for addressing health equity. [WATCH TIME: 4 minutes]