Detecting the Earliest Signs of Alzheimer Disease and Brain Amyloid Status
August 22nd 2021Michael Weiner, MD, professor of radiology and biomedical imaging, medicine, psychiatry, and neurology at the University of California–San Francisco, discussed the findings of a systematic review aimed at evaluating models that predict dichotomous Aß.
BTK Inhibitor Fenebrutinib Aims to Tackle Progressive MS in FENtrepid Trial
August 20th 2021The agent’s safety profile has been studied in more than 1200 individuals to date across several inflammatory diseases, with data indicating that the high selectivity of fenebrutinib may limit off-target effects.
Miniature Brain Model Aims to Reduce Cost, Accelerate Drug Discovery for Alzheimer Disease
August 20th 2021Yanhong Shi, PhD, director, stem cell biology research, City of Hope National Medical Center, discussed the potential of a new brain organoid model, which was developed to study sporadic Alzheimer disease.
Filling a Critical Need for Idiopathic Hypersomnia With JZP-258 (Xywav)
August 19th 2021After the FDA approval for Jazz Pharmaceuticals' oxybates combination therapy, Robert Iannone, MD, MSCE, offered insight into the potential effects the drug may have on the clinical care of patients with idiopathic hypersomnia.
Associations Between Contrast-Enhancing Lesions and MS Disease Spectrums Raise Questions
August 18th 2021Multivariable logistic regression models found age to be the only characteristic associated with the risk of CELs at baseline in all datasets, with a higher age associated with a lower risk of CELs.
Potential for Alzheimer Drug Development With Miniature Brain Models: Yanhong Shi, PhD
August 18th 2021The director of stem cell biology research at City of Hope spoke on the newly developed brain organoid, which has the potential to help investigators identify pathological mechanisms of Alzheimer disease.
NeuroVoices: James Galvin, MD, MPH, on Location and Greenhouse Space Effects on Alzheimer Risk
August 18th 2021The director of the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine provided context on greenhouse spaces and their preventive benefits in Alzheimer disease.
Miniature Brain Model Has Clinical Implications for Alzheimer Disease: Yanhong Shi, PhD
August 17th 2021Yanhong Shi, PhD, director of stem cell biology research at City of Hope, discussed the new brain organoid, which was derived from human induced pluripotent stem cell technology to better study and understand sporadic Alzheimer disease.
New Platform Helps Interpret Neuromodulation Data Into Actionable Insights for Epilepsy
August 17th 2021The chief medical officer of NeuroPace discussed the newly developed nSight Platform, which allows physicians to remotely track seizure burden and activity for patients with drug-resistant focal epilepsy.
Miniature Brain Models May Inform Alzheimer Disease Research, Clinical Trials: Yanhong Shi, PhD
August 16th 2021The director of the division of stem cell biology research at City of Hope discussed the potential of the model to study the mechanistic causes of Alzheimer disease and to test dementia drugs currently in development.
It Is Time to Redefine Outcomes in Pediatric Epilepsy Surgery
August 16th 2021Successful epilepsy surgery in adults has been followed by forced normalization, depression, and memory issues, resulting in questions about the use of the metrics in the study of broader outcomes—a problem even more prominent in pediatric epilepsy surgery.