Sanjeev V. Thomas, MD, DM: Managing Epilepsy During Pregnancy
June 26th 2019The chief of neurology at Sree Chitra Tirunal Institute for Medical Sciences and Technology spoke about how to reassure patients with epilepsy who are planning for pregnancy and how to make treatment decisions with pregnant patients.
Sleep Disorders Have Significant Impact on Patients With Epilepsy
June 25th 2019Several poster presentations at IEC 2019 suggest that the incidence of comorbid sleep disorders in people with epilepsy is higher than estimated and have a detrimental impact on quality of life and social adjustment.
Hannah Cock, MD, MBBS: Challenges in Treating Status Epilepticus
June 25th 2019The professor of epilepsy and medical education at St. George’s University Hospital London spoke about the number of challenges plaguing epileptologists when treating patients who present with possible status epilepticus in the hospital.
Perampanel Does Not Worsen Myoclonic or Absence Seizures in Patients With Epilepsy
June 24th 2019Overall, myoclonic and absence seizures worsened in 1.2% and 15.9% more patients in the placebo group, respectively, than those given perampanel. The reductions in seizure frequency and the increases in seizure-free days were also greater with the noncompetitive AMPA receptor antagonist.
Perampanel Monotherapy Promotes Seizure Freedom in Previously Untreated Partial Onset Epilepsy
June 23rd 2019Preliminary results from the 4 mg maintenance period of the FREEDOM study, the first in which perampanel has been examined as monotherapy, were presented at the 2019 International Epilepsy Congress in Bangkok.
Andrew Russman, DO: There's No Sleeping on Advancements in Stroke
June 21st 2019The head of the Cleveland Clinic stroke program and medical director of the Comprehensive Stroke Center sat down with Neurology Live for an in-depth discussion on stroke certifications, advanced treatment technology, and the ever-evolving concept of "time is brain."
THX-110 Shows Promise in Obstructive Sleep Apnea With Interim Phase 2a Results
June 21st 2019Four of the 7 patients exhibited significant improvement in all assessed study parameters, which included reduction in the Apnea-Hypopnea Index scale and an improvement in oxygen desaturation index, with 1 patient demonstrating mild improvement; overall THX-110 was generally well tolerated.
Amy B. Sullivan, PsyD: Screening MS Patients for Comorbidities
June 21st 2019The director of behavioral medicine at the Mellen Center for MS Treatment and Research at Cleveland Clinic discussed the importance of screening patients with MS for other conditions for which they are prevalently comorbid, such as depression or sleep disorders.
Peter Goadbsy, MD, PhD, DSc: Atogepant Has Potential as Migraine Prophylactic
June 20th 2019The professor of neurology at both the University of California San Francisco and King’s College, London, spoke about the results from a phase 2b/3 study evaluating atogepant for prevention of migraine.
Nilvadipine Increases Hippocampal Blood Flow in Alzheimer Disease
June 20th 2019While the clinical benefit of the therapy in Alzheimer is still unclear, the dihydropyridine calcium channel blocker increased blood flow by 20% compared to placebo in the brain’s memory and learning center, indicative of preserved cerebral autoregulation.
Phyllis C. Zee, MD, PhD: Insomnia, a Clinical Diagnosis
June 19th 2019The director of the center for circadian and sleep medicine at Northwestern University spoke about the importance of recognizing insomnia as a clinical diagnosis since it affects patients 24-hours a day, not just during sleep.
Deferiprone Slows PKAN Disease Progression, Marking An Important Step in Treatment
June 18th 2019Despite the clinical benefit being limited, the slowing of pantothenate kinase-associated neurodegeneration disease progression—particularly in atypical cases—is a step toward developing a treatment for the orphan disease.
Laura T. Safar, MD: Carefully Addressing Mental Health in MS
June 18th 2019The director of MS neuropsychiatry at Brigham and Women’s Hospital spoke of the importance of not oversimplifying the approach to mental health disorders in individuals with MS, and how the collaborative care model can help.­­­
Neurofilament Light Shows Multi-disease Usefulness in Measuring Axonal Damage
June 17th 2019The systematic review and meta-analysis identified cNfL usefulness as a biomarker, with the potential to help differentiate between frontotemporal dementia and Alzheimer disease, as well as Parkinson disease from atypical parkinsonian syndromes.