Research Makes Headway in Dementia With Lewy Bodies and the Influx of Gene Therapy
The president of the ANA offered his perspective on these novel genetic therapies, as well as other a few other areas of interest.
Case Report: Sudden Mutism
Could 20 years of treatment for migraine have prompted a spontaneous absence of speech after this patient stopped taking her medication?
Could Diabetes Medications Reduce Alzheimer Disease Severity?
The professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai spoke about new study findings that suggest antidiabetic therapy could reduce Alzheimer genetic expression.
Rolf Fronczek, PhD, MD: Narcolepsy and Opiates
The neurologist discussed an analysis of findings suggesting that opiate agonists may have a role in the treatment of narcolepsy.
Epilepsy, the Perfect Paradigm in Implementing Telemedicine
The clinical professor in pediatric neurology and director of regional neurology services at Children's Hospital Colorado shared her thoughts on why epilepsy is the perfect paradigm to implement telemedicine.
Sodium Oxybate Approved, ANAVEX 2-73 Shows Positive Results, Ubrogepant for Acute Migraine Care, and Stroke Risk with Migraine
Neurology News Network for the week of November 3, 2018.
Concomitant Use of Cholinesterase Inhibitors, Memantine May be Confounded with Outcomes in Alzheimer Clinical Trials
In clinical trials, differences in the use of cholinesterase inhibitors and memantine between treatment and placebo groups may lead to the conclusion that a treatment is effective when it is not, or vice versa.
Oral Film Clobazam Given FDA Go-Ahead for Lennox-Gastaut Syndrome
This is the first oral film formulation of clobazam approved, highlighting the challenge of medication administration in patients with LGS, who often struggle due to physical, behavioral, or cognitive impacts.
Robert J. Fox, MD: Treating Progressive Multiple Sclerosis
The neurologist from Cleveland Clinic discussed the challenges of treating progressive MS, and shared his clinical experience with ibudilast.
Young Fresh Frozen Plasma Proves Feasible for Alzheimer Symptom Amelioration
Although treatment needs to be assessed in a larger trial, it also showed improvements in 2 measurements of functional ability.
Dystonia, A Disorder Longing for More Therapies
The Pediatric Movement Disorders Neurologist at UT Southwestern recommends that when encountering a patient with a movement disorder to organize your thought process in 3 steps.
Treatment With Antidiabetic Medications Shows Effect on Alzheimer Disease Genetic Expression
The compromised microvascular and insulin receptor signaling pathways seen in Alzheimer disease have been shown to be reduced or normalized by exposure to antidiabetic therapies.
Searching for a Biomarker in MS: Neurofilament Light Chain
The medical director of clinical development at Biogen spoke about the current use of the biomarker and the steps being taken clinically validate it.
Kate Davis, MD, MSTR: Referring Patients to An Epileptologist
The epileptologist discussed this challenge, and shared her thoughts on how to maintain this communication.
Immune System Reconstitution in Multiple Sclerosis With Cladribine Tablets
The director of the Comprehensive Multiple Sclerosis Center at Thomas Jefferson University provided insight on the potential effect cladribine could have on multiple sclerosis.
AMBAR Data Revealed Significant Reduction in the Progress of Alzheimer Disease
Trial results showed a reduction of 61% in disease progression in both primary efficacy endpoints measuring cognition and activities of daily living at 14 months.
Neurology Comic: How Do I Change My Genes?
I have Huntington disease in my family. How do I change my genes?
Claire Henchcliffe, MD, DPhil: Dopaminergic Cell Replenishment in Parkinson Disease
The associate professor of neurology and neuroscience at Weill Cornell Medicine discussed this work, and what she and her colleagues believe could be addressed by a successful effort.
Tideglusib Improves Myotonic Dystrophy Type 1 Neuromuscular Symptoms
In its second phase 2 trial, the therapy, also known as AMO-02, resulted in improvements in cognitive function, fatigue, and neuromuscular symptoms.
The Impact of CGRP Inhibitors on Patients and Providers
The president of the American Headache Society shared her thoughts on how preventive medicines can alter migraine treatment for the better.
When Your Patients Have Recurrent Dreams
People of all ages occasionally report recurrent dreams, and there is an established association between negative dreams and daytime anxiety.
Bernd Feige, PhD: Insomnia and the REM Sleep State
The study presents direct evidence that subjective experiences of insomnia may be coupled to the REM sleep state.
Spinal Muscular Atrophy, Questions That Remain Unanswered
Darryl De Vivo, MD, emphasized that while there's been a tremendous advance in the field of SMA, it’s important to continue tinkering around the margins to make the effective treatment increasingly better.
Zonisamide Improves Parkinsonism in Dementia with Lewy Bodies
Zonisamide improved Parkinsonism as an adjunct to levodopa in patients with dementia with Lewy bodies in phase 3 trial.
George Koshy Vilanilam, MBBS: Migraine as a Risk Factor for Ischemic Stroke
The study found that there has been a significant increasing trend in patients with migraine—irrespective of aura status—having an ischemic stroke.
FDA Approves Expanded Use for Sodium Oxybate in Cataplexy, Excessive Daytime Sleepiness in Pediatric Narcolepsy
Sodium oxybate is the first therapy approved to treat cataplexy or excessive daytime sleepiness in pediatrics with narcolepsy 7 years of age and older.
Lingering Unmet Needs in Acute Migraine Treatment
Despite the explosion of preventive medications for migraine, a large need for acute care remains.
Spinal Muscular Atrophy, From Bench to Bedside
The Sidney Carter Professor of Neurology at Columbia University Medical Center spoke about the 127 year history of spinal muscular atrophy and how basic science has led to exciting developments.
Customized Injections Enhance Botulinum Toxin for Essential Hand Tremor
Customizing injection sites and amounts of botulinum toxin for different presentations of essential hand tremor has been shown to avoid hand weakness.
Anna Heidbreder, MD: Anti-IgLON5 Disease, REM Sleep Behavior Disorder
Heidbreder further described the current understanding of the condition and what she and her colleagues have found out.