Donepezil Shows No Effect on Development of Psychosis in Parkinson
The results suggest that early use of donepezil may be efficacious against cognitive decline but not for the prophylaxis of psychosis.
An Incidental Finding
A 67-year-old woman comes to the urgent care because she fell in the shower three days ago. She insists that she doesn’t have any symptoms and she says her fall resulted from a slip on soap.
Helping Patients with Parkinson, Huntington Live Well
When physicians can’t rid patients of their disease, it’s important to remember that they can still help patients live well with it.
'Never Events' Common for Patients with Comorbid Parkinson, Dementia
Almost 45% of those who received an antidementia treatment experienced the never event of co-administration of a high-potency anticholinergic medication and an acetylcholinesterase inhibitor.
Jan Hedner, MD, PhD: Current Therapeutic Landscape of Obstructive Sleep Apnea
Recent research has identified novel potential pathophysiological mechanisms that could potentially serve to subclassify various phenotypes in obstructive sleep apnea.
Eva Winnebeck, PhD: Movement Rhythms During Sleep
The actimetry-based method allows for easily quantifiable sleep dynamics in real life context, enabling large-scale clinical studies to investigate the complex temporal dynamics of sleep.
Krista Lanctot, PhD: Managing Patients with Agitation
Lanctôt advised ruling out any possible underlying medical conditions that could be causing it, including pain, as well as starting with any non-pharmacologic interventions.
Geert Mayer, MD: Safety, Efficacy of Solriamfetol for Excessive Sleepiness In Narcolepsy, OSA
Long-term maintenance of efficacy was demonstrated with solriamfetol for treatment of excessive sleepiness with narcolepsy or obstructive sleep apnea.
Galcanezumab Approved, Pimavanserin Safety Confirmed, Treating Augmentation in RLS, Genetics in Alzheimer
Neurology News Network for the week of September 28, 2018.
Perampanel Receives Expanded Indication From FDA For Pediatrics With Partial-Onset Seizures
Safety data for pediatrics was consistent with the safety profile in adult populations, without the need for weight-based dosing.
Irina Pikuleva, PhD: Activating CYP46A1 with Efavirenz
The Carl F. Asseff Professor of Ophthalmology and the Director of the Visual Sciences Research Center at Case Western Reserve University spoke about the beginnings of her work with efavirenz.
Pimavanserin Safety Reiterated in Independent Study
An independent investigation out of UC San Diego has found no statistically significant evidence showing a higher risk of mortality with the therapy compared to quetiapine or combination therapy.
Geert Mayer, MD: Solriamfetol As Potential Therapy for Excessive Sleepiness in Narcolepsy, Obstructive Sleep Apnea
The neurologist and sleep specialist spoke about data from one of many studies investigating solriamfetol for treatment of narcolepsy and obstructive sleep apnea with remaining excessive daytime sleepiness.
Potential Parkinson Targets to Improve Care
The movement disorder specialist in the Henry Ford Health System spoke about the needs for improving treatment and diagnosis of Parkinson disease.
DEA Reschedules Epidiolex, Allowing Therapy to Enter US Market
GW Pharmaceuticals stated that it plans to bring the drug to market in the United States in the next 6 weeks.
Galcanezumab Gets FDA Go-Ahead for Migraine Prevention
This approval marks the third of its kind in the calcitonin gene-related peptide inhibitor class, starting with erenumab in May 2018.
Vaccination During Pregnancy and Autism Risk
Is Tdap vaccination linked to increased ASD risk? A study of over 80,000 children provides insights.
Ibudilast Phase III Program in ALS Moving Forward
The anti-inflammatory agent is also being explored in progressive MS, with phase II results reading out earlier this year.
Paul Newhouse, MD: Attacking Different Targets in Alzheimer
The Jim Turner Chair in Cognitive Disorders at the Vanderbilt University School of Medicine shared his feelings on the early phase treatments.
Differences in Juvenile Huntington Disease Manifestations Identified
A retrospective analysis has established clinical distinctions between expressions of juvenile Huntington disease, suggesting a need for a reclassification.
Daphne Chylinski: Arousals During Sleep Are Strongly Linked to Alzheimer Disease Pathophysiology
Chylinski spoke about the relationship between the increased number of arousals during sleep and the pathogenesis of Alzheimer disease.
In Alzheimer, Precision of Phrasing is Paramount
The Director of Cleveland Clinic’s Lou Ruvo Center for Brain Health discussed the importance of clarity in patient identification and assessment.
Guiding Principles in Reducing Stroke Mortality
Stroke survivors with hypertension who are recommended earlier antihypertensive treatment and lifestyle modification may greatly increase their chances of survival.
Probable OSA Common in Patients With Epilepsy, Linked to SUDEP Risk
A pilot study has identified a potential link between obstructive sleep apnea and a higher risk of sudden unexpected death in epilepsy.
Assessing, Recognizing Severe Augmentation in RLS
The restless leg syndrome expert discussed how general neurologists can best identify and address newly diagnosed patients, as well as what has changed in recent years.
Howard Fillit, MD: The Importance of Biomarkers for Alzheimer Disease
Fillit spoke about remaining need for additional biomarkers in Alzheimer, and what has been developed in recent years.
Light to Moderate Physical Activity Can Lower Stroke Severity
New research has added to the growing body of research suggesting a wide range of health benefits from light physical activity.
The Gene Therapy Dilemma in Huntington Disease
With the planned submission of an IND for the first AAV gene therapy for the rare genetic condition, some experts are wondering if things are moving too quickly.
Krista Lanctot, PhD: Addressing Alzheimer Disease Agitation
The psychiatry and pharmacology professor at the University of Toronto and senior scientist at Sunnybrook Research Institute spoke about the use of cannabinoids to treat agitation in Alzheimer.
The Neurobiology of Forgiveness
To err is human; to forgive, divine. Or is it? Research on the brain’s structural anatomy and activity provide insight into the science of forgiveness.