Victoria Johnson, Assistant Editor for GeneTherapyLive, joined the MJH Life Sciences team in October 2020, originally writing for NeurologyLive. Follow her on Twitter @VictoriaJNeuro or email her at vjohnson@genetherapylive.com.
Natalizumab Improves Social and Mental Health in Patients with Multiple Sclerosis
Researchers compared Neuro-QoL scores between patients treated with natalizumab and ocrelizumab, another high-efficacy treatment for MS.
Improving Patient Understanding and Treatment Adherence in Obstructive Sleep Apnea
William Noah, MD, director and founder of the Sleep Centers of Middle Tennessee discussed issues in caring for patients with OSA.
IMU-838 Efficacious and Well-Tolerated in Relapsing Multiple Sclerosis
The therapy has fewer off-target effects on kinases and may be better-tolerated than other DHODH inhibitors for patients with relapsing MS.
Lower-Sodium Oxybate Has Similar Efficacy, Easily Transitions From Higher-Sodium Oxybate
Researchers saw the least amount of adverse events and the least time to stable dose in participants entering the study with SXB treatment.
Telestroke Accurately Distinguishes Ischemic Stroke From Stroke Mimics
Researchers from the University of Utah analyzed the use of their telestroke system with 27 outside “stroke” facilities.
African American Women Experience Greatest Disadvantage in Post-Stroke Rehabilitation
Researchers analyzed disparities in stroke rehab and found that women and African Americans had the lowest functional performance.
Treatment Disparities, Neurologic Complications Clarified by COVID-19 Neurological Research
The 2021 AAN Meeting Hot Topics plenary focused on neurological facets of COVID-19, and featured insight from Anthony Fauci, MD, of NIAID, and Walter Koroshetz, MD, of NINDS, among others.
Simple Interventions Improve Compliance With Patient-Specific Stroke Discharge Instructions
Researchers from Ascension Saint Agnes improved compliance in their hospital in providing patient-specific, stroke-dedicated discharge instructions.
Negative Impacts on Cognition Not Observed With Pimavanserin for Dementia-Related Psychosis
The study presented at the 2021 AAN Meeting follows the complete response letter issued by the FDA to Acadia Pharmaceuticals due to deficiencies in their sNDA.
Personalized Cladribine Dosing for Multiple Sclerosis
Kimberly Allen-Philbey, a PhD candidate at the Barts MS Center in London, discussed the advantages of using a personalized dosing schedule of off-label, subcutaneous cladribine.
Minorites May Receive Less Timely MCI Diagnoses Than White Individuals
Researchers analyzed data from the 10,472 Medicare beneficiaries diagnosed with mild cognitive impairment or dementia in California.
Treating Paramagnetic Rim Lesions in Multiple Sclerosis
Jemima Akinsanya, DO, Neuroimmunology Clinical Fellow at the National Institutes of Health, discussed new studies of anakinra and tolebrutinib in MS.
Does Early DMT Prescription Prevent Conversion to Clinically Definite Disease?
Ilena George, MD, of Massachusetts General Hospital, discussed a cohort of patients with early DMT prescription and low rates of clinical conversion.
New DMD Quality of Life Questionnaire Accurately Assesses Adults and Children
Researchers used patient, family, and public engagement to develop a 14-item DMD-QoL questionnaire.
Stroke Hospitalizations and IVT Decreased Globally During COVID-19 Pandemic
Researchers collected data from 457 stroke centers in 70 countries encompassing 6 continents, which included more than 80,000 stroke hospitalizations.
The Rarity of Adverse Events With Natalizumab Infusion for MS
Yujie Wang, MD, a neurologist from the University of Washington Medical Center, discussed examining the 1-hour post monitoring period of natalizumab infusion amid the COVID-19 pandemic.
Study Clarifies Associations Between Alzheimer Biomarkers and MRI Measures
Researchers studied associations between CSF neurofilament light, neurogranin, and t-tau with measures of cortical thickness, white matter hyperintensities, and microstructural integrity.
Myelin Cervical Cord Abnormalities Can Serve as Marker of MS Progression
Researchers found significant differences between clinically relevant areas in participants with progressive MS, relapsing MS, and healthy controls.
Predicting MS Disability: IL-1 Receptor Antagonist or Neurofilament Light?
Stephanie Blandford, MSc, a PhD candidate at Memorial University of Newfoundland, discussed some advantages of using IL-1RA over NfL in predicting disability in multiple sclerosis.
rtPA Effective in Ischemic Stroke Prior to Recanalization Despite Occlusion
Researchers studied concentrations of recombinant tissue plasminogen activator locally and systemically in patients with IS.
EFF-Nanotransfected Fibroblast Injection Could Treat Ischemic Stroke
Researchers found a 70% infarct resolution and 90% motor recovery in mice injected with the EFF-nanotransfected cells.
GV1001 Efficacious and Well-Tolerated in Alzheimer Disease
Researchers found improvements in SIB and NPI score between high-dose and placebo groups.
Reviewing Decisions and Evidence on Aducanumab for Alzheimer Disease
Researchers on the FDA’s advisory committee conducted a review of the studies and evidence ahead of the treatment’s PDUFA date on June 7, 2021.
PF-06939926 Continues to Show Safety and Efficacy in Duchenne Muscular Dystrophy
An update on the phase 1b study of Pfizer’s investigational DMD treatment was presented at the MDA 2021 conference.
IV Edaravone Reduces Chance of Death, Tracheostomy, PAV, and Hospitalization in ALS
Researchers conducted a post-hoc analysis of Study 19 to determine hazard ratios of milestone occurrences in amyotrophic lateral sclerosis.
SGT-001 Shows Improvements in Key DMD Measures, Microdystrophin Expression
Preliminary results from the IGNITE-DMD trial also showed a decreased in creatine kinase levels and improvements on NSAA and PODCI.
Sleep Apnea Associated With Visceral Adiposity in Elderly, General Adiposity in Non-Elderly
Researchers studied associations between obstructive sleep apnea and varied markers of adiposity.
Pulse Wave Amplitude Identifies Respiratory Events in Pediatric Polysomnography
Researchers found that taking into account PWA increased total arousal index more than 3-fold.
Patients With COVID-19 and Stroke Are Younger With Worse Severity and Outcomes
Researchers conducted a systematic review of studies reporting on patients with both COVID-19 and stroke and found worse outcomes compared to patients with stroke alone.
Serum GFA Protein: An Accurate Biomarker for Neuromyelitis Activity, Attack Risk
Researchers analyzed levels of sGFAP in participants from the N-MOmentum study that assessed inebilizumab (Uplizna; Viela Bio) in relapsing-remitting MS.