Victoria Johnson, Assistant Editor for GeneTherapyLive, joined the MJH Life Sciences team in October 2020, originally writing for NeurologyLive. Follow her on Twitter @VictoriaJNeuro or email her at vjohnson@genetherapylive.com.
Increasing Prevalence of Early DMT Prescription in Radiologically Isolated Syndrome
Researchers from Massachusetts General Hospital found that DMT-treated patients were, on average, younger than untreated patients.
Natalizumab Infusion Reports Strong Safety Profile, Rarely Causes Adverse Events in Relapsing MS
Researchers from the University of Washington Medical Center analyzed data from almost 10,000 infusions of natalizumab.
Instrumented Postural Sway Test Differentiates Fallers From Non-Fallers in MS
Researchers investigated the test, which is normally used to differentiate people with MS from healthy controls, in a population of those with multiple sclerosis.
New Studies Evaluating Anakinra and Tolebrutinib on Paramagnetic Rim Lesions in MS
The trial of anakinra is underway, while the trial for tolebrutinib is undergoing regulatory review.
TNFαi-Associated CNS Demyelination Persists After Treatment Discontinuation
Researchers retrospectively analyzed patient follow-ups and found that 50% of patients were ultimately diagnosed with multiple sclerosis.
Intensive Motor Arm Therapy Improves mRS Scores in Poststroke Patients
Similar proportions of both in-clinic and telemedicine patients had modified Rankin scale score improvements.
Common Migraine Interventions Ineffective in Reducing Disease Burden
A recent study investigated self-reported outcomes of preventive treatment prior to the introduction of calcitonin gene related peptide (CGRP) receptor targeting.
Investigating Stem Cell Therapy in TBI and Other Conditions
Bijan Nejadnik, MD, chief medical officer, SanBio, also thanked neurological experts that collaborated on the phase 2 STEMTRA trial.
Decreased Ischemic Stroke Admissions and Telestroke Consultations During Pandemic
Researchers also found that during the COVID-19 pandemic, there were reduced rates of stroke quality of care measures.
Lower Amyloid Levels Observed in Black People Despite Higher Alzheimer Disease Risk
Racial disparities in biomarkers highlight the need to investigate different populations in trials of Alzheimer disease.
SB623 Stem Cell Therapy to Regain Motor Function in TBI
Masahito Kawabori, MD, PhD, associate professor, Hokkaido University, discussed results of the phase 2 STEMTRA trial.
Cognitive Behavioral Therapy for Chronic Insomnia
Jennifer Martin, PhD, AASM board of directors' member and professor of medicine at UCLA discussed CBI-T and some of the challenges in treating patients with chronic insomnia.
Higher Rates of Thyroid Disease in Alemtuzumab-Treated Patients With MS
Researchers also found that patients treated with autologous hematopoietic stem cell transplantation had higher rates of infection then other DMT-treated groups.
First Patient Dosed With AL002 in Phase 2 Early Alzheimer Disease Study
Alector’s announcement about the INVOKE-2 study follows a similar update regarding its INFRONT-3 study for frontotemporal dementia.
Age of Onset and Vision Loss in Neuromyelitis Optica Spectrum Disorders
The neurologist from Cleveland Clinic discussed how patients with early-onset NMOSD were more likely to have severe residual vision loss.
Evias Plus Simulation System Improves Thrombectomy Training
The Biomodex-developed models have also been studied in pre-procedural rehearsal for brain aneurysms.
Previously Unrecognized Dystonia is a Prevalent Clinical Feature of Angelman Syndrome
Researchers found that 93% of patients with AS exhibited dystonia in their limbs, mouth, neck, or trunk.
Brain Neurotherapy Bio Brings Clinical Programs for Parkinson and MSA to AskBio
Both therapeutic programs utilize AAD2-GDNF gene therapy targeted to brain structures vulnerable to Parkinson disease and multiple system atrophy.
West and West-like Syndrome Most Common Severe Epilepsy Syndromes at Infancy
Researchers found that infantile epileptic encephalopathy and SEI with migrating focal seizures had the highest mortality rates at 2 years of age.
Older Adults With Epilepsy Experience Faster Cognitive Decline
Mini-mental state exam scores declined significantly faster in adults with prevalent and incident epilepsy, while digit symbol substitution test scores declined significantly faster in prevalent epilepsy.
Idiopathic Intracranial Hypertension More Likely With High BMI, Socioeconomic Deprivation
Socioeconomic deprivation was associated with IIH independently of BMI in women but not men.
OnabotulinumtoxinA Approved for Pediatric Neurogenic Detrusor Overactivity
The treatment can be used in children who do not respond well to anticholinergic medications.
Hematopoietic Stem Cell Implantation Prevents Disability Worsening in Patients With MS
While patients with relapsing-remitting MS were found to benefit more from aHSCT, patients with progressive MS still experienced stability in disability scores.
Soticlestat Reduces Seizure Frequency in Children With Dravet Syndrome
Despite significant improvements in Dravet syndrome, non-statistically significant reductions were observed in children with Lennox-Gastaut Syndrome.
QRA-244 Shows Promise in Slowing ALS in Preclinical Studies
The chief scientific officer of QurAlis discussed how QRA-244 is more specific and potent than retigabine, a treatment currently in clinical studies.
Cerebral Microhemorrhages Predict Faster Worsening on CDR-SB Score
Researchers compared CMH rates in PSEN1, PSEN2, and APP mutation carriers and noncarriers of dominantly inherited Alzheimer disease.
High Adherence With Integrated Sleep Practice-Supplied PAP Machines in Disturbed Sleep Breathing
Researchers also observed that PAP machines from ISPs were used for a longer median duration than those from DMEs.
Videoconferencing for Preclinical Alzheimer Cognitive Composite Score is Accurate, Accessible
Researchers found that time between assessments was the only predictor of PACC score differences.
Occlusion Site, Thrombus Length Are Good Predictors of ENDi in Minor Stroke, LVO
A score based on these variables was found to show good discrimination and calibration in predicting early neurological deterioration of ischemic origin, or ENDi.
Atabecestat Associated With Cognitive Worsening in Alzheimer Disease
The results suggest that BACE-1 inhibitors, while a promising option to slow progression of Alzheimer disease, require further study with careful safety monitoring.