Victoria Johnson, Assistant Editor for GeneTherapyLive, joined the MJH Life Sciences team in October 2020, originally writing for NeurologyLive. Follow her on Twitter @VictoriaJNeuro or email her at vjohnson@genetherapylive.com.
Investigating Disparities in Post-Stroke Rehabilitation
Sana Somani, MD, MBBS, vascular neurology fellow at the University of Maryland Medical Center, discussed her research into disparities in post-stroke care.
Patients With Chronic Migraine More Likely to Face Barriers to Successful Migraine Care
A recent paper supported by several presentations at AAN 2021 elucidate areas of migraine care to improve.
Improving Post-Stroke Outcomes With Personalized Discharge Instructions
Marian LaMonte, MD, MSN, FAAN, chief of neurology at Ascension Saint Agnes, discussed her team’s efforts to improve compliance in providing stroke discharge instructions.
Patients With Essential Tremor Experience High Economic Burden
A budget impact analysis suggested that Cala Health’s Cala Trio device can serve as a cost-saving treatment option for patients with ET.
Assessing Accuracy in Teleneurology for Stroke Consultations
Jason Poon, MD, neurologist at University of Utah, discussed his study on diagnostic accuracy in telestroke consultations.
Study Design for Phase 3 PHOENIX Trial for AMX0035 in ALS Announced
The trial design was presented at the 2021 ENCALS meeting and is set to run for 48 weeks at more than 50 clinical centers.
Arimoclomol Fails to Show Efficacy in ALS
The investigational drug, previously granted fast-track designation, did not meet primary or secondary end points in the ORARIALAS-01 trial.
Veterans Affairs Investigates gammaCore for Treatment of Post-Traumatic Headache
The study will be based in West Haven, Connecticut, and enroll up to 100 veterans with the headache disorder.
Investigating IMU-838 for Relapsing MS
Robert Fox, MD, Vice-Chair for Research at the Cleveland Clinic Neurological Institute, discussed the findings of the phase 2 EMPhASIS trial of this investigational MS therapy.
Shriners Hospital and Jackson Laboratory to Collaborate on Genetic Research in Cerebral Palsy
The 2 organizations will use whole-genome sequencing and clinical characterization to investigate the genetic causes of CP.
SGT-001 Continues to Show Safety and Efficacy in DMD
Data presented at the ASGCT 2021 meeting showed increased microdystrophin expression with SGT-001.
Recombinant Factor Vlla to be Studied as Intracerebral Hemorrhage Treatment
Northwell Health will conduct a NIH-funded study assessing the effects of the experimental drug in treating patients with ICH.
Encouraging OSA Testing and Awareness Among Physicians
William Noah, MD, director and founder of the Sleep Centers of Middle Tennessee, discussed the aim of his practice’s study.
Study Identifies High Number of Comorbidities in Patients With Migraine
In addition to comorbidity frequency, the researchers also studied the comparison of comorbidities between men and women with migraine.
Pimavanserin: Hopes for FDA Approval in Dementia-Related Psychosis
Clive Ballard, MD, the executive dean at the University of Exeter Medical School, discussed the safety and efficacy profile of pimavanserin (Nuplazid; Acadia Pharmaceuticals).
Biogen and Capsigen Collaborate to Develop New AAV Capsids for CNS, Neuromuscular Disorders
The partnership combines Capsigen’s vector engineering with Biogen’s drug pipeline, seeking to develop gene therapies for neuromuscular and central nervous system disorders.
The Remaining Necessities for Future Progressive MS Research
Kathy Zackowski, PhD, OTR, senior director of patient management, care, and rehabilitation research at the National MS Society discussed her team’s call to action for research.
Investigational C6-17 Reduces Mutant Huntingtin Protein and Improves Motor Performance
A recent study showed improvements in animals with mutant huntingtin protein treated with AFFiRiS AG’s investigational monoclonal antibody.
Targeting Chronic Inflammation in Progressive MS
Daniel Reich, MD, PhD, senior investigator at the National Institutes of Neurological Disorders and Stroke, spoke about his investigations into the role of microglia in progressive MS.
Polygenic Hazard Score Predicts Parkinson Disease Progression to Dementia
A recent study identified 3 novel loci that are associated with Parkinson disease progression to dementia: RIMS2, TMEM108, and WWOX.
TNFαi Inhibitors and CNS Demyelination
Spencer Hutto, MD, a fellow of autoimmune neurology at Massachusetts General Hospital, discussed his team’s investigation into demyelinating events after the use of TNFαi inhibitors.
GammaCore nVNS Deemed Effective for Acute Treatment, Prevention of Cluster Headache
A recent review outlined the clinical features, pathophysiology, and treatments for cluster headache, finding noninvasive vagus nerve stimulation to be effective in various ways.
FAST Grant Enables Creation of Angelman Syndrome Hotline
Recent Foundation for Angelman Syndrome Therapeutics grants funded the hotline as well as work to develop cell line models for rarer genotypes of AS.
Abnormal Cardiac Autonomic Response Observed Prior to SUDEP
Researchers found that patients with epilepsy that later died from SUDEP had an abnormal cardiac response after hyperventilation.
Dyskinesia and OFF Time Disruptions Seen in Most Patients with Parkinson Disease
A survey of more than 500 individuals also found that dyskinesia impacted social interactions and reported that OFF time was isolating.
Survey Clarifies World Trends in Narcolepsy Care
The World Sleep Society Narcolepsy Task Force surveyed clinicians in an effort to understand regional differences in the diagnosis and management of narcolepsy.
PAP Therapy Adherence Rates Lower In Latin America Than US
Investigators also studied how use of a patient engagement tool influenced adherence rates to PAP.
Fitbit Displays Accuracy Compared to Polysomnography Measures in Children and Adolescents
Researchers compared sleep measures between the Fitbit Charge 3, the Actigraph GT9X accelerometer, and polysomnography.
Active MRIs Pre-Pregnancy Predict Postpartum Relapse in MS
Researchers also found that EDSS score pre-pregnancy was associated with the likelihood of post-partum relapse for patients with multiple sclerosis.
Improving Standards of Sleep Apnea Care
William Noah, MD, director and founder of the Sleep Centers of Middle Tennessee, discussed findings from his study on PAP adherence.