Understanding Smoldering Disease in MS Beyond Focal Inflammatory Activity: Antonio Scalfari, MD, PhD
September 10th 2024The consultant neurologist at Imperial College Healthcare Trust talked about how smoldering disease in multiple sclerosis encompasses disease progression independent of relapsing activity, thus broadening the scope beyond traditional measures. [WATCH TIME: 4 minutes]
Safety Considerations for Tolebrutinib and Utility of BTK Inhibitors: Erik Wallstroem, MD, PhD
September 10th 2024The global head of neurology development at Sanofi discussed the safety profile of tolebrutinib, an investigational BTK inhibitor, and how treatments like it may help transform the care for patients with multiple sclerosis. [WATCH TIME: 5 minutes]
Helping to Expand Global Care for the Duchenne Muscular Dystrophy Patient Community: Debra Miller
September 7th 2024The chief executive officer and founder at CureDuchenne discussed efforts to bring specialized physical therapy and infrastructure support to underserved regions to improve care for patients impacted by Duchenne worldwide. [WATCH TIME: 5 minutes]
Promise and Potential Challenges With Gene Therapy in Epilepsy: Imad Najm, MD
September 5th 2024The director of Cleveland Clinic’s Epilepsy Center at the Cleveland Clinic Neurological Institute provided commentary on the future outlook of gene therapies for patients with epilepsy, and some of the knowledge and technical barriers clinicians currently face. [WATCH TIME: 5 minutes]
Overviewing Cleveland Clinic’s International Epilepsy Summit: Imad Najm, MD
August 30th 2024The director of Cleveland Clinic’s Epilepsy Center at the Cleveland Clinic Neurological Institute discussed the parameters of an upcoming educational event that highlights the current and future role of sEEG in epilepsy surgery. [WATCH TIME: 5 minutes]
Therapeutic Potential of Combination Strategies to Treat Alzheimer Disease: Lloyd Tran, PhD
August 28th 2024The chairman and chief executive officer at Biomed discussed the additive benefits of combination therapy for Alzheimer disease, providing context on the strengths of different drugs and how it might lead to a more precision medicine approach. [WATCH TIME: 6 minutes]
Treatments With Higher Efficacy and Relapses in NMOSD
August 28th 2024This discussion examines how disability accumulation may be influenced by the use of less efficacious treatments, compares the efficacy of novel and traditional NMOSD agents in clinical practice, and reviews relapse rates associated with FDA-approved treatments versus off-label and older therapies.
Raising Awareness for Spinal Muscular Atrophy and Improving Newborn Screening: Crystal Proud, MD
August 27th 2024The director of neurology and neuromuscular medicine at the Children’s Hospital of the King’s Daughters in Norfolk, Virginia, discussed SMA Awareness Month and the enhancements to newborn screening for the disease. [WATCH TIME: 4 minutes]
Development of the DAAE Score for Predicting Progression in Multiple Sclerosis: Tom Fuchs, MD, PhD
August 22nd 2024The postdoctoral researcher at Amsterdam University Medical Center talked about the development of the DAAE score, a tool for predicting the risk of transition to secondary progressive multiple sclerosis. [WATCH TIME: 8 minutes]
Expanding the Potential to Treat Alzheimer Disease With RNA Therapeutics: Sharon Cohen, MD, FRCPC
August 21st 2024The medical director of the Toronto Memory Program at the University of Toronto gave clinical perspective on the promise of mivelsiran, an investigational RNA interference therapeutic, and the idea behind using RNA therapies to treat Alzheimer disease. [WATCH TIME: 5 minutes]
Exploring Cognitive Motor Dissociation in Consciousness Disorders: Nicholas Schiff, MD
August 19th 2024The Jerold B. Katz professor of neurology and neuroscience at Weill Cornell Medicine talked about a recent study that revealed patients who appeared unresponsive to verbal commands in vegetative or minimally conscious states retained high cognitive function. [WATCH TIME: 6 minutes]
Future Directions and Unanswered Questions Regarding S1P Modulator Receptors
August 17th 2024In this episode, Patricia Coyle, MD, FAAN, gave clinical insight on some of the next steps regarding S1P-modulating therapies, including some of the advantages of newer generation agents and the need for future studies to investigate benefits and limitations to each.