Discovering a New Receptor for Nerve Growth Factor: Nigel Bunnett, PhD, BSc
January 10th 2025The professor and chair of the Department of Molecular Pathobiology at NYU College of Dentistry provided a clinical overview of preclinical research identifying a new receptor for nerve growth factor that plays an important role in pain signaling. [WATCH TIME: 4 minutes]
Overlapping Diagnoses and the Advancement of MS Detection in NMDARE: Joseph Kuchling, MD
January 7th 2025The postdoctoral research assistant at Charité University Berlin discussed advances in diagnostic criteria and 7-Tesla MRI imaging, highlighting a previously overlooked overlap between anti-N-methyl-D-aspartate receptor encephalitis and multiple sclerosis. [WATCH TIME: 5 minutes]
Managing Disease Progression in MS: Changing Treatments and Clinician Advice
January 7th 2025Panelists discuss how in multiple sclerosis (MS) treatment, clinicians must strategically evaluate disease progression, considering within-class or mechanism-of-action switches. Comprehensive monitoring, personalized approaches, and proactive management are crucial for optimizing patient outcomes and minimizing long-term neurological disability.
Advancing Future Drug Development for Narcolepsy: Mihaela Nowak, MD
January 6th 2025The neurologist and sleep disorder specialist at Allegheny Health Network provided an in-depth exploration of the current advancements and future directions in narcolepsy drug development. [WATCH TIME: 3 minutes]
Evolving MS Diagnostics From Categorical Classifications to Biological Phenotyping: Fred Lublin, MD
January 3rd 2025The director of the Corinne Goldsmith Dickinson Center for MS at Mount Sinai talked about the shift in multiple sclerosis diagnostics from rigid classification systems to a dynamic, spectrum-based approach focused on biological phenotyping. [WATCH TIME: 5 minutes]
Evaluating Cognitive Health: Tools, Markers, and the Concept of Cognitive PIRA
December 23rd 2024Panelists discuss how clinicians can evaluate cognitive health using neuroimaging, cerebrospinal fluid (CSF)/blood biomarkers, and comprehensive assessments. Understanding concepts like cognitive progressive irreversible reductions in activity (PIRA) and focusing on multifaceted interventions—including lifestyle modifications, early detection, and personalized strategies—can help maintain cognitive wellness and mitigate decline.
Long-Term Cognitive Effects of Cladribine: SDMT Score Changes in the CLARIFY-MS Extension Study
December 23rd 2024Panelists discuss how the CLARIFY-MS extension study revealed stable cognitive function 4 years post cladribine, highlighting the potential of early treatment to preserve cognitive capabilities in multiple sclerosis (MS) patients. Cognitive assessments remain crucial for monitoring disease progression and tailoring patient management.
Novel Approach to Antiseizure Drug Development With Use of Long Episodes: Jacqueline A. French, MD
December 17th 2024The professor of neurology at NYU Grossman School of Medicine discussed a pioneering study using long seizure episodes to optimize treatment devices and identify effective antiseizure drugs in epilepsy care. [WATCH TIME: 2 minutes]
Exploring DMTs: Blood-Brain Barrier Penetration and Cognitive Health Benefits
December 16th 2024Panelists discuss how disease-modifying therapies (DMTs) like dimethyl fumarate, fingolimod, and cladribine demonstrate potential blood-brain barrier penetration, offering neuroprotective mechanisms. While these therapies show promise in mitigating cognitive decline, their impacts vary, highlighting the complex interplay among neuroinflammation, immune modulation, and cognitive preservation in multiple sclerosis management.
Addressing PIRA in Clinical Practice and Patient Conversations
December 16th 2024Panelists discuss how in managing multiple sclerosis (MS), clinicians must adopt a comprehensive approach to progressive irreversible reductions in activity (PIRA) that prioritizes early detection, transparent communication, and patient empowerment. By integrating regular cognitive assessments, providing compassionate and clear explanations, and emphasizing proactive management strategies, physicians can help patients navigate the complex cognitive landscape of MS, ultimately preserving quality of life and fostering patient resilience in the face of neurological challenges.
Using SEEG Data to Decode Brain Activity for Decision-Making: Alexander C. Whiting, MD
December 13th 2024The director of epilepsy surgery at Allegheny Health Network talked about recent advances in brain signal analysis with stereoelectroencephalography and its potential for transforming care for decision-making disorders. [WATCH TIME: 4 minutes]