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Opinion|Videos|June 3, 2024

Alzheimer’s Disease Pipeline

Author(s)Richard Isaacson, MD, Sharon Cohen, MD, FRCPC, Marwan Sabbagh, MD

Key opinion leaders discuss the Alzheimer's disease pipeline and the numerous disease-modifying therapies under investigation.

Episodes in this series

EP. 1 Apolipoprotein E4 in Alzheimer’s Disease

EP. 1 Apolipoprotein E4 in Alzheimer’s Disease

EP. 2 Importance of Early Diagnosis of Alzheimer’s Disease

EP. 2 Importance of Early Diagnosis of Alzheimer’s Disease

Video 3 - "Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease"

EP. 3 Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease

video 4 - "Amyloid Cascade Hypothesis of Alzheimer’s Disease"

EP. 4 Amyloid Cascade Hypothesis of Alzheimer’s Disease

Video 5 - "Contribution of Multiple Pathways to the Development of Alzheimer’s Disease"

EP. 5 Contribution of Multiple Pathways to the Development of Alzheimer’s Disease

Video 6 - "Utilization of Neuroimaging in Alzheimer’s Disease"

EP. 6 Utilization of Neuroimaging in Alzheimer’s Disease

A panel of 3 experts on Alzheimer's disease

EP. 7 CSF Testing and Blood-based Biomarkers in Alzheimer’s Disease

A panel of 3 experts on Alzheimer's disease

EP. 8 Utilization of APOE4 Genotype in Management of Alzheimer’s Disease

A panel of 3 experts on Alzheimer's disease

EP. 9 Alzheimer’s Disease Pipeline

A panel of 3 experts on Alzheimer's disease

EP. 10 The Future Outlook for Alzheimer’s Disease

Video content above is prompted by the following question:

Please provide an overview of robust Alzheimer’s pipeline and many disease modifying therapies under investigation.
Discuss novel and emerging treatments that are most advanced in clinical studies or have promising data:
- Valiltramiprosate (ALZ-801,inhibits amyloid oligomer formation, oral)
- ALN-APP (RNAi therapeutic)
- Blarcamesine (sigma-1 and muscarinic receptors ligand)

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