Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease

The panel provides an overview of amyloid precursor protein (APP) and the generation of amyloid β (Aβ) peptides, Aβ42 and Aβ40, while also discussing which soluble or insoluble Aβ species (monomers, oligomers, protofibrils, or amyloid plaques) contribute to neuronal damage and the clinical manifestation of Alzheimer's disease.

EP: 1.Apolipoprotein E4 in Alzheimer’s Disease

EP: 2.Importance of Early Diagnosis of Alzheimer’s Disease

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EP: 3.Amyloid Precursor Protein and Amyloid Beta Species in Alzheimer’s Disease

EP: 4.Amyloid Cascade Hypothesis of Alzheimer’s Disease

EP: 5.Contribution of Multiple Pathways to the Development of Alzheimer’s Disease

EP: 6.Utilization of Neuroimaging in Alzheimer’s Disease

EP: 7.CSF Testing and Blood-based Biomarkers in Alzheimer’s Disease

EP: 8.Utilization of APOE4 Genotype in Management of Alzheimer’s Disease

EP: 9.Alzheimer’s Disease Pipeline

EP: 10.The Future Outlook for Alzheimer’s Disease

What is amyloid precursor protein (APP)? How are amyloid β (Aβ) peptides, Aβ42 and Aβ40, generated?

Which soluble or insoluble species of Aβ (monomers, oligomers, protofibrils or amyloid plaques) contribute to neuronal damage and clinical manifestation of Alzheimer’s disease?