Opinion|Videos|May 6, 2024

Apolipoprotein E4 in Alzheimer’s Disease

Author(s)Richard Isaacson, MD
Sharon Cohen, MD, FRCPC

Sharon Cohen, MD, and Marwan Sabbagh, MD, differentiate between the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD), and highlight known risk factors, including the contribution of ApoE gene polymorphism and copy numbers.

Video content above is prompted by the following question(s):

How are different stages of Alzheimer’s disease (AD; preclinical AD, prodromal AD, and AD with dementia) defined?
1. What are known risk factors for Alzheimer's disease?
  1. Contribution of ApoE gene polymorphism and copy numbers
2. When do patients with Alzheimer’s typically present to the clinic?

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