This is a video synopsis/summary of a panel discussion involving Michael Thorpy, MD; Karl Doghramji, MD, FAASM, DFAPA; Clete Kushida, MD, PhD; and Richard K Bogan, MD.

Experts discusses considerations for changing medications in narcolepsy patients due to side effects or declining effectiveness. The decision-making process for switching medications is highlighted, with a focus on assessing symptoms, particularly excessive daytime sleepiness, at each encounter with the patient. Objective testing, such as overnight studies with the Multiple Sleep Latency Test (MSLT), may be necessary, especially if subjective history is unreliable. Special populations, such as commercial drivers, may require additional tests like Maintenance of Wakefulness Test (MWT) to ensure safety. Patient-reported outcome measures, including sleep-related questionnaires and scales for anxiety and depression, are used to monitor treatment response. However, questionnaire fatigue is acknowledged, and careful consideration is given to the frequency and variety of assessments to minimize patient burden while still ensuring comprehensive monitoring of symptoms and treatment effectiveness.

Video synopsis is AI-generated and reviewed by NeurologyLive editorial staff.