Current Treatment Options for Dravet Syndrome

Author(s):

Key Takeaways

The primary treatment goal for Dravet syndrome is reducing seizure frequency and severity while improving quality of life and minimizing side effects.
Initial treatments for Dravet syndrome include valproate and clobazam, which are effective in managing seizures.
Escalation therapy options, such as stiripentol, cannabidiol, and fenfluramine, are used when initial treatments are insufficient, providing additional seizure control.

The panelist discusses how the goal of Dravet syndrome treatment is to reduce seizure frequency and severity, typically starting with initial treatments like valproate and clobazam and potentially escalating to combination therapies including options such as cannabidiol, with the overall aim of improving patients’ quality of life and developmental outcomes

EP: 1.Expert Dravet Syndrome Overview

EP: 2.Dravet Syndrome Diagnosis

EP: 3.Dravet Syndrome: Comorbidities and Patient Quality of Life

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EP: 4.Current Treatment Options for Dravet Syndrome

EP: 5.Challenges Associated With Dravet Syndrome Treatment

EP: 6.Dravet Syndrome and Caregiver Burdens

EP: 7.Final Thoughts on Dravet Syndrome Management

Video content above is prompted by the following:

What is the goal of treatment for Dravet syndrome?
- Please describe the recommended initial treatments for Dravet syndrome.
  - Valproate
  - Clobazam
Please describe treatment options that are available as escalation therapy in combination with initial treatments for Dravet syndrome.
- Stiripentol
- Cannabidiol
- Fenfluramine